Pimobendan (hydrochloride)

Name	Pimobendan (hydrochloride)
Synonyms	PiMobendan (hydrochloride) Pimobendan (hydrochloride) 4,5-Dihydro-6-[2-(4-methoxyphenyl)-1H-benzimidazol-5-yl]-5-methyl-3(2H)-pyridazinone monohydrochloride
CAS	77469-98-8

Molecular Formula	C19H19ClN4O2
Molar Mass	370.83276
Melting Point	311°(dec)
Solubility	10 mM in DMSO
Storage Condition	-20℃
In vitro study	Pimobendan hydrochloride (UD-CG115 hydrochloride) exhibits selective inhibition of PDE III isolated from guinea pig cardiac muscle with IC 50 of 0.32 uM compared to the inhibition of PDE I and PDE II (IC 50 >30 μM). In human atrial cells, 100 μM Pimobendan (UD-CG115) significantly increases the L-type calcium current (ICa(L)) (evoked by depolarization to +10 mV from a holding potential of -40 mV) by 250.4% with the half-maximal stimulation (EC 50 ) of 1.13 μM. In rabbit atrial cells, Pimobendan (UD-CG115) increases ICa(L) at +10 mV by 67.4.%, which is significantly lower than that obtained in human atrial cells.
In vivo study	Pimobendan (UD-CG115) shows a beneficial effect on survival in the murine model of EMC virus-induced myocarditis. Administration of Pimobendan (UD-CG115) significantly increases the final survival rate from 33.6% (control) to 53.3% (0.1 mg/kg) or 66.7% (1 mg/kg). Pimobendan (UD-CG115) (1 mg/kg) also significantly reduces myocardial cellular infiltration, the level of intracardiac tumor necrosis factor (TNF)-α and interleukin (IL)-1β compared with the control group, which shows no effect on myocardial necrosis, heart weight and body weight. Pimobendan (UD-CG115) suppresses expression of the intracardiac iNOS gene , causing reduction of intracardiac NO production.

Toxicity

LD50 orally in mice: ~600 mg/kg (Austel, 1982)

Spot supply

Product Name: UD-CG115 hydrochloride Visit Supplier Webpage Request for quotation
CAS: 77469-98-8
Tel: 609-228-6898
Email: sales@medchemexpress.com
　　　　 tech@medchemexpress.com
Mobile: 609-228-6898

Spot supply

Product Name: Pimobendan hydrochloride Visit Supplier Webpage Request for quotation
CAS: 77469-98-8
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328

WhatsApp: +86-18821248368

Product Name: Pimobendan (hydrochloride) Visit Supplier Webpage Request for quotation
CAS: 77469-98-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Spot supply

Spot supply

Product Name: Pimobendan hydrochloride Visit Supplier Webpage Request for quotation
CAS: 77469-98-8
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328

WhatsApp: +86-18821248368

Product Name: Pimobendan (hydrochloride) Visit Supplier Webpage Request for quotation
CAS: 77469-98-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

View History

Pimobendan (hydrochloride) Request for Quotation